Imputation of truncated p-values for meta-analysis methods and its genomic application
نویسندگان
چکیده
منابع مشابه
Imputation of Truncated p-Values For Meta-Analysis Methods and Its Genomic Application.
Microarray analysis to monitor expression activities in thousands of genes simultaneously has become routine in biomedical research during the past decade. a tremendous amount of expression profiles are generated and stored in the public domain and information integration by meta-analysis to detect differentially expressed (DE) genes has become popular to obtain increased statistical power and ...
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Truncated product method for combining P-values.
We present a new procedure for combining P-values from a set of L hypothesis tests. Our procedure is to take the product of only those P-values less than some specified cut-off value and to evaluate the probability of such a product, or a smaller value, under the overall hypothesis that all L hypotheses are true. We give an explicit formulation for this P-value, and find by simulation that it c...
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15 صفحه اولMicroarray missing values imputation methods: Critical analysis review
Gene expression data often contain missing expression values. For the purpose of conducting an effective clustering analysis and since many algorithms for gene expression data analysis require a complete matrix of gene array values, choosing the most effective missing value estimation method is necessary. In this paper, the most commonly used imputation methods from literature are critically re...
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ژورنال
عنوان ژورنال: The Annals of Applied Statistics
سال: 2014
ISSN: 1932-6157
DOI: 10.1214/14-aoas747